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Allopurinol

Allopurinol

Allopurinol is used to treat gout, kidney stones, and tophi (uric acid deposits in tissues), which are caused by excessive levels of uric acid in the blood. It is also used to prevent elevated blood uric acid levels in patients undergoing cancer chemotherapy. Allopurinol works by reducing the production of uric acid in your body. This medicine may also be used to treat other conditions as determined by your doctor.
Category: Kidney Stones
Medically Reviewed by – Dr. Leo Barrett, MD
Last Updated on 8 July 2026

What is Allopurinol used for?

Allopurinol is used to treat gout, kidney stones, and tophi (uric acid deposits in tissues), which are caused by excessive levels of uric acid in the blood. It is also used to prevent elevated blood uric acid levels in patients undergoing cancer chemotherapy. Allopurinol works by reducing the production of uric acid in your body. This medicine may also be used to treat other conditions as determined by your doctor.

What are the allopurinol side effects?

Allopurinol, like many medicines, can cause side effects, though not everyone will experience them. Common and mild symptoms usually settle with time. Possible side effects include:
  • Skin rash or itching
  • Nausea or vomiting
  • Diarrhoea
  • Drowsiness or dizziness
  • Changes in liver function tests
  • Headache
Serious reactions are rare but can occur. If you notice a severe rash, fever, or swelling, stop taking Allopurinol and contact your doctor immediately for advice.

What are the symptoms of gout?

Typical symptoms of gout come on suddenly and can be quite painful. They often affect one joint at a time, most commonly the big toe.

  • Severe joint pain – sharp, throbbing pain, often starting at night

  • Swelling and warmth around the joint

  • Red, shiny skin that feels tender to touch

  • Stiffness or limited movement after a flare

  • Peeling or itchy skin once swelling eases

  • Recurrent attacks may affect ankles, knees, or fingers over time

What is the recommended dosage of Allopurinol?

The dosage of Allopurinol prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

What if you miss a dose of Allopurinol?

If your physician has instructed or directed you to take Allopurinol medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.

What if you overdose on Allopurinol?

Any medication taken in excess can have serious consequences. If you suspect an overdose of Allopurinol, seek medical attention immediately.

What other drugs could interact with Allopurinol?

It may be noted that drugs other than those listed above may also interact with Allopurinol. Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Allopurinol, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions. Allopurinol can interact with blood thinners and antibiotics. Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

Where can I buy allopurinol over the counter in the UK?

A high uric acid level can lead the gout or gouty arthritis like condition (including joint pain and inflammation). Allopurinol online over the counter medication is a xanthine oxidase inhibitor that works by decreasing the uric acid that is produced by the body. This Allopurinol alternative or branded Allopurinol is available only with the doctor's prescription and Allopurinol without prescription is not available.

Can I buy Allopurinol without a prescription?

Allopurinol without prescription is used to treat gout and kidney stones. It is also prescribed for having some types of cancer treatment. Some treatments can also lead to build-up of uric acid. This medicine comes as 100mg and 300mg tablets and is only available on prescription.

Does allopurinol shorten your life?

No, allopurinol doesn’t shorten your life. In fact, when taken correctly, it can help prevent gout attacks and long-term joint damage. It also reduces the risk of kidney stones and other complications caused by high uric acid. Regular check-ups and proper dosing are key to keeping your health in good order.

What to avoid when taking allopurinol?

Avoid drinking too much alcohol, especially beer and spirits, as they can raise uric acid levels. Cut back on purine-rich foods such as red meat, shellfish, and organ meats. Stay well hydrated, and never skip doses or stop treatment suddenly without speaking to your doctor. Certain antibiotics and diuretics should also be used cautiously.

Why does allopurinol worsen acute gout?

Allopurinol may initially worsen gout because it changes uric acid levels in your body too quickly. This sudden shift can trigger crystal movement in joints, causing inflammation and pain. Doctors often prescribe anti-inflammatory medicines at the start of treatment to help manage these early flare-ups until levels stabilise over time.

What are the questions to ask your doctor before taking Allopurinol tablet?

Is it possible for me to take Allopurinol with other drugs? Should certain beverages, foods and other products be avoided when I take Allopurinol? What are the possible drug interactions of Allopurinol? How will Allopurinol work in my body? How should Allopurinol be taken? How to reduce the risk of Allopurinol drug interactions and side effects?

Warnings and Precautions

The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Allopurinol is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.

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