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Trazodone

Trazodone

Trazodone is an antidepressant medication used to treat depression. It works by restoring the balance of serotonin in the brain. This drug is also prescribed to treat insomnia, chronic pain, panic attacks, aggressive behavior, and anxiety disorders. This medicine may also be used to treat other conditions as determined by your doctor.
Medically Reviewed by – Dr. Aaron Fletcher, MD
Last Updated on 13 July 2026

What does Trazodone Tablets treat?

Trazodone Tablets is used to treat depression and falls into the category of anti-depressants. It helps restore the balance of serotonin in the brain. It also is used to treat anxiety disorders, insomnia, chronic pain, panic attacks and aggressive behavior. It helps in improving the mood, appetite and energy levels.

Possible Side Effects

Trazodone Tablets might have some side effects but it’s not possible to anticipate them. It does not have any major side effects and these are temporary. In rare cases, there might be major side effects and immediate medical attention must be sought. Side effects may include dizziness, weight loss, increase in blood pressure, nausea, drowsiness, diarrhea, headache, dry mouth, insomnia, lack of appetite, muscle pain and more. Serious side effects that could occur include shortness of breath, severe headache, hallucinations, twitching of muscles and Serotonin syndrome. This list however is not exhaustive. Always follow your physician’s instructions strictly.

Dosage Instructions

Follow the Trazodone dosage prescribed by your physician. The dosage could vary based on individual patient requirements. Always follow your physician’s instructions or go by the directions on the prescription drug label.

What is Dosage Trazodone for Sleep?

Trazodone Dosage for Sleep: Adults and Children

Trazodone is commonly prescribed off-label for sleep disorders. The dosage for adults typically starts at 25-50 mg before bedtime. Your healthcare provider may gradually increase it to 100-150 mg if needed. However, dosages above 150 mg are usually not recommended solely for sleep. For children, trazodone is less commonly used, and its safety and effectiveness for sleep have not been well-studied. Pediatric dosing should only be determined by a healthcare provider, based on the child’s specific needs and medical history. Never give trazodone to a child without consulting a doctor. Always take trazodone as directed and avoid alcohol or other sedatives while using it. Common side effects include drowsiness, dizziness, and dry mouth. If you experience severe side effects or signs of an allergic reaction, seek immediate medical attention. Before starting trazodone for sleep, talk to your healthcare provider to determine the best dosage for your needs and to discuss any potential risks or interactions with other medications.

Missed a dose?

Take it immediately once you remember. In case, this time is closer to the next dosage, skip it and get back to the prescribed schedule. Never take a double dose. abc

Overdosed?

Don’t waste any time and seek immediate medical attention. An overdose could result in unusual dizziness, vomiting, drowsiness, rapid or irregular heartbeat, seizures, and more.

Drug Interactions

Drug interactions must be considered before starting to take any kind of drug. Drug interactions might happen either when Trazodone is taken along with another drug or with particular foods. To prevent any kind of negative interaction, make sure you inform your doctor of any drugs you are taking including non-prescription medication, OTCs, health supplements like vitamins, minerals, herbal medicine and so on which may increase the effect of Trazodone.
  • Trazodone may interact with
  • Carbamazepine,
  • Digoxin,
  • Indinavir,
  • Ketoconazole
Taking MAO inhibitors such as Isocarboxazid, Linezolid, Methylene Blue, Moclobemide, Phenelzine, Procarbazine, Rasagiline, Safinamide, Selegiline, and Tranylcypromine may result in adverse reactions that could be quite serious in nature. It may also interact with antifungal medicines, seizure medicines, and HIV medication. This is not an exhaustive list though. Appraise your doctor of any medical conditions that you are suffering from and your family history of medical ailments. It’s important that you do not stop or start taking any medicine without the consent of your physician.

Is Trazodone an Over the Counter Medicine?

No, Trazodone is not an over-the-counter medicine. It's a prescription-only antidepressant, regulated by the FDA in the US (and equivalent bodies elsewhere), typically prescribed for depression, anxiety, or insomnia. Because it affects brain chemistry and carries risks like drowsiness, blood pressure changes, and drug interactions, medical supervision is required. Always consult a licensed physician or pharmacist before use — never self-medicate with prescription drugs.

Do you need a prescription for trazodone?

Yes, trazodone requires a prescription in most countries. It is an antidepressant used for conditions like depression, anxiety, and sleep problems, so a doctor must confirm it is safe for you. A healthcare professional will check your symptoms, medical history, and current medicines before prescribing it. You should not buy or use trazodone without proper medical guidance.

What to ask your doctor before you start on Trazodone Tablet?

  • Can I take Trazodone along with other drugs? 
  • Are there certain foods, beverages and products to be avoided while on Trazodone? 
  • What is the dosage of Trazodone to be consumed? 
  • How should I use Trazodone? 
  • How will Trazodone work on my body? 
  • How can the drug interactions and side effects of Trazodone be minimized or completely avoided?

Disclaimer

The health and medical information that we have provided is meant to supplement and not substitute the advice of your physician, pharmacists, or other health care professionals. This does not suggest that usage of Trazodone is safe, appropriate, or effective for you. Always ensure that you take this or any other drug only after consulting your physician.  

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