What is Flucloxacillin Sodium 500mg Used For?
Flucloxacillin Sodium 500mg is an antibiotic that fights bacterial infections. It belongs to the penicillin group, working by stopping bacteria from growing. Doctors prescribe it for skin infections, bone infections, respiratory infections, and soft tissue infections. It also treats boils, abscesses, cellulitis, and infected wounds.
This antibiotic is also useful after surgery to prevent infections. In some cases, it helps with conditions like osteomyelitis (bone infections) and endocarditis (heart infections). Unlike some antibiotics, Flucloxacillin targets specific bacteria, making it less likely to harm good bacteria in your body.
Since it is a prescription medicine, you should only take it as directed by your doctor. Stopping early can lead to antibiotic resistance, making infections harder to treat in the future.
How to Take Flucloxacillin Sodium 500mg?
To get the best results, take Flucloxacillin on an empty stomach. This means:
- One hour before meals or two hours after meals
- Swallow the capsule whole with water
- Do not chew or crush the capsule
If you miss a dose, take it as soon as you remember. But if it's almost time for your next dose, skip the missed dose. Never take two doses at the same time.
For the best effect, take the medicine at evenly spaced times. This keeps the right amount of medicine in your blood. Avoid alcohol while taking Flucloxacillin, as it may affect how the drug works.
Dosage Instructions
The dosage depends on the type and severity of your infection. General guidelines include:
- Adults & children over 10 years: 500mg every 6 hours
- Children (2-10 years): 250mg every 6 hours
- Children under 2 years: 125mg every 6 hours
For severe infections, your doctor may increase the dose or recommend an intravenous (IV) injection. Always complete the full course, even if you feel better. Stopping early may cause the infection to return.
Flucloxacillin side effects
Like all medicines, Flucloxacillin can cause side effects. Common ones include:
- Nausea or vomiting
- Diarrhea or stomach pain
- Skin rash or itching
- Headache or dizziness
Rare but serious side effects:
- Liver problems (yellowing of skin or eyes)
- Severe allergic reaction (swelling, difficulty breathing)
- Severe diarrhea (bloody stools, dehydration)
If you experience severe side effects, seek medical help immediately.
Drug Interactions
Flucloxacillin can interact with other medicines, changing how they work. Let your doctor know if you take:
- Blood thinners (Warfarin) – may increase bleeding risk
- Methotrexate – may cause toxicity
- Probenecid – may raise Flucloxacillin levels
- Oral contraceptives – effectiveness may decrease
Taking antibiotics unnecessarily can reduce their effectiveness, so only use them if prescribed.
Warnings
Before taking Flucloxacillin, inform your doctor if you:
Are allergic to penicillin
Have kidney or liver problems
Are pregnant or breastfeeding
Have a history of gut infections (like colitis)
Do not share this medicine with others. Misuse of antibiotics leads to resistant bacteria, making infections harder to treat.
Storage
To keep Flucloxacillin effective:
- Store at room temperature (below 25°C / 77°F)
- Keep in a dry place away from moisture
- Do not freeze
- Keep out of reach of children
Do not use expired medicine. If your doctor stops the medication, dispose of it safely.
FAQ
Can You Drink Alcohol on Flucloxacillin Sodium?
It is not recommended to drink alcohol while taking Flucloxacillin Sodium 500mg. Although alcohol does not directly interfere with the antibiotic, it can weaken your immune system and make side effects like nausea, dizziness, or stomach upset worse. To ensure the best results, avoid alcohol until you complete the treatment.
When Is the Best Time to Take Flucloxacillin Sodium 500mg?
Take Flucloxacillin on an empty stomach for best absorption. This means taking it one hour before meals or two hours after eating. Swallow the capsule with a full glass of water. Taking it at evenly spaced intervals helps maintain steady levels in your bloodstream, making it more effective at fighting infections.
What Is the Washout Period for Flucloxacillin Sodium 500mg?
Flucloxacillin usually stays in your system for 6–8 hours after the last dose. However, to completely clear it from your body, the washout period is around 24 to 48 hours. This can vary based on kidney function, age, and metabolism. If switching to another medication, consult your doctor about proper timing.
Where to Buy Flucloxacillin Sodium 500mg?
Flucloxacillin Sodium 500mg is available at local pharmacies, online, and prescription-based platforms. Ensure you buy from licensed pharmacies to get genuine medication. Some online platforms offer home delivery, but always check for certified suppliers and valid prescriptions before purchasing.





