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Sertraline 100mg
Medically Reviewed by – Dr. Aaron Fletcher, MD
Last Updated on 9 July 2026

Sertraline 100mg

$1.31 $1.60

Sertraline 100mg is a prescription-strength medication widely trusted in modern psychiatry. It belongs to a family of drugs called Selective Serotonin Reuptake Inhibitors (SSRIs). Clinically, this specific dosage is commonly prescribed to treat major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder (SAD), and premenstrual dysphoric disorder (PMDD).

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Categories: Anti depressantsTag: Pills

What Is Sertraline 100 mg and What Is It Used For?

Sertraline 100 mg is a prescription antidepressant that belongs to the selective serotonin reuptake inhibitor (SSRI) class of medicines. It is commonly prescribed when lower doses are not providing adequate symptom control or when a healthcare provider determines that a higher maintenance dose is appropriate. Sertraline works by increasing serotonin activity in the brain, which helps regulate mood, emotions, and anxiety symptoms.

Sertraline 100 mg may be prescribed for:

  • Major Depressive Disorder (MDD)
  • Obsessive-Compulsive Disorder (OCD)
  • Panic Disorder
  • Post-Traumatic Stress Disorder (PTSD)
  • Social Anxiety Disorder
  • Premenstrual Dysphoric Disorder (PMDD)

Quick Facts About Sertraline 100 mg

Key Information Details
Generic Name Sertraline
Strength 100 mg
Drug Class Selective Serotonin Reuptake Inhibitor (SSRI)
Form Oral Tablet
Prescription Required Yes
Common Uses Depression, OCD, Anxiety Disorders
Typical Administration Once Daily
Maximum Adult Dose Up to 200 mg daily as prescribed

How Does Sertraline 100 mg Work?

Sertraline increases serotonin levels by blocking the reabsorption (reuptake) of serotonin in nerve cells. Higher serotonin availability helps improve mood stability, reduce anxiety, decrease obsessive thoughts, and support emotional well-being. Unlike sedatives, sertraline is not intended for immediate symptom relief and may take several weeks to achieve its full therapeutic effect.

How to Take Sertraline 100 mg?

Take Sertraline 100 mg exactly as prescribed by your healthcare provider.

  • Take once daily at the same time each day.
  • Can be taken with or without food.
  • Swallow the tablet whole with water.
  • Continue treatment even if symptoms improve unless instructed otherwise.
  • Do not stop treatment suddenly, as discontinuation symptoms may occur.

Dosage Information

The appropriate dosage depends on the condition being treated, symptom severity, age, and response to treatment.
Condition Typical Daily Dose
Depression 50–200 mg
OCD 50–200 mg
Panic Disorder 25–200 mg
PTSD 25–200 mg
Social Anxiety Disorder 25–200 mg
Many patients who respond well to treatment remain on 100 mg daily as a maintenance dose. Dose adjustments should only be made under medical supervision.

Alternative dosage of Sertraline:-

Sertraline 25mg Sertraline 100mg

Common Side Effects of Sertraline 100 mg

Some patients experience mild side effects during the first few weeks of treatment.

Common side effects include:

  • Nausea
  • Diarrhea
  • Dry mouth
  • Increased sweating
  • Headache
  • Dizziness
  • Tremor
  • Sleep disturbances
  • Fatigue
  • Reduced libido
  • Delayed ejaculation or sexual dysfunction

Seek immediate medical attention if you experience:

  • Severe allergic reactions
  • Suicidal thoughts or behavior changes
  • Seizures
  • Serotonin syndrome symptoms
  • Unusual bleeding or bruising

Drug Interactions

Sertraline may interact with several medicines, including:

  • Monoamine Oxidase Inhibitors (MAOIs)
  • Linezolid
  • Lithium
  • Tramadol
  • St. John’s Wort
  • Blood thinners such as warfarin
  • NSAIDs including ibuprofen and naproxen
  • Other antidepressants
  • Migraine medicines that affect serotonin levels

Inform your healthcare provider about all prescription medicines, supplements, and herbal products before starting treatment.

Important Warnings and Precautions

Sertraline may not be suitable for everyone.

Speak with your healthcare provider before use if you:

  • Have liver disease
  • Have a history of seizures
  • Have bipolar disorder
  • Have glaucoma
  • Are pregnant or planning pregnancy
  • Are breastfeeding
  • Have a history of bleeding disorders

Antidepressants carry a boxed warning regarding an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults during the initial stages of treatment. Careful monitoring is recommended.

Pregnancy and Breastfeeding

Sertraline should only be used during pregnancy when the potential benefits outweigh the risks. Exposure during late pregnancy may affect newborns and requires medical supervision.

Sertraline can pass into breast milk. Patients should discuss risks and benefits with their healthcare provider before breastfeeding.

Overdose

Symptoms of overdose may include:

  • Excessive drowsiness
  • Nausea and vomiting
  • Tremors
  • Rapid heartbeat
  • Agitation
  • Serotonin syndrome symptoms

Seek emergency medical care immediately if an overdose is suspected.

Missed Dose

If you miss a dose:

  • Take it as soon as you remember.
  • Skip the missed dose if it is almost time for your next scheduled dose.
  • Do not take two doses together to make up for a missed dose.

Storage

Store Sertraline 100 mg tablets:

  • At room temperature between 20°C and 25°C (68°F–77°F)
  • Away from moisture and heat
  • In the original container
  • Out of reach of children and pets

FAQ

How long does Sertraline 100 mg take to work?

Some patients notice improvement within 1 to 2 weeks, but the full therapeutic effect may take 4 to 8 weeks depending on the condition being treated and individual response.

Is Sertraline 100 mg a high dose?

Sertraline 100 mg is considered a common maintenance dose. Depending on clinical response, healthcare providers may prescribe doses ranging from 50 mg to 200 mg daily.

Can Sertraline 100 mg cause weight gain?

Weight changes can occur during treatment. Some patients experience weight loss initially, while others may notice weight gain with long-term use. Individual responses vary.

What is the price Sertraline 100mg?

The price of Sertraline 100mg varies based on quantity ordered, the pharmacy you choose, and whether you have insurance or a discount coupon. Generally, larger quantities offer a lower cost per tablet than smaller ones. Promotional offers can further reduce the total price. Since cost varies by source, it’s best to check current pricing directly and confirm the pharmacy is licensed before purchasing, to ensure both value and safety.

Is Sertraline 100mg a prescription medication?

Yes. Sertraline 100mg is a prescription medication. It should be taken only when prescribed by a licensed healthcare provider. Do not start, stop, or change the dose without medical advice.

Is Sertraline 100mg available over the counter?

No. Sertraline 100mg is not available over the counter. It is a prescription-only medicine, so it should be used only after a licensed healthcare provider confirms it is suitable for your condition and explains the correct dosage, precautions, and possible interactions.

Medical Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Sertraline 100 mg should be used only as prescribed by a qualified healthcare provider. Always consult your doctor before starting, stopping, or changing any medication. Seek immediate medical attention if you experience serious side effects or an allergic reaction.

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