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Allopurinol

Allopurinol

Allopurinol is used to treat gout, kidney stones, and tophi (uric acid deposits in tissues), which are caused by excessive levels of uric acid in the blood. It is also used to prevent elevated blood uric acid levels in patients undergoing cancer chemotherapy. Allopurinol works by reducing the production of uric acid in your body. This medicine may also be used to treat other conditions as determined by your doctor.
Category: Kidney Stones
Medically Reviewed by – Cooper Hastings, PharmD
Last Updated on 8 July 2026

What is Allopurinol used for?

Allopurinol is used to treat gout, kidney stones, and tophi (uric acid deposits in tissues), which are caused by excessive levels of uric acid in the blood. It is also used to prevent elevated blood uric acid levels in patients undergoing cancer chemotherapy. Allopurinol works by reducing the production of uric acid in your body. This medicine may also be used to treat other conditions as determined by your doctor.

What are the side effects of Allopurinol?

Like other medicines, Allopurinol can cause some side effects. If they do occur, the side effects of Allopurinol are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately. It is pertinent to note that side effects of Allopurinol cannot be anticipated. If any side effects of Allopurinol develop or change in intensity, the doctor should be informed as soon as possible. Allopurinol can cause side effects such as nausea, vomiting, diarrhea, and dizziness. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Allopurinol.

What is the recommended dosage of Allopurinol?

The dosage of Allopurinol prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

What if you miss a dose of Allopurinol?

If your physician has instructed or directed you to take Allopurinol medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.

What if you overdose on Allopurinol?

Any medication taken in excess can have serious consequences. If you suspect an overdose of Allopurinol, seek medical attention immediately.

What other drugs could interact with Allopurinol?

It may be noted that drugs other than those listed above may also interact with Allopurinol. Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Allopurinol, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions. Allopurinol can interact with blood thinners and antibiotics. Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

Where can I buy Allopurinol online over the counter?

A high uric acid level can lead the gout or gouty arthritis like condition (including joint pain and inflammation). Allopurinol online over the counter medication is a xanthine oxidase inhibitor that works by decreasing the uric acid that is produced by the body. This Allopurinol alternative or branded Allopurinol is available only with the doctor's prescription and Allopurinol without prescription is not available.

Can I buy Allopurinol without a prescription?

Allopurinol without prescription is used to treat gout and kidney stones. It is also prescribed for having some types of cancer treatment. Some treatments can also lead to build-up of uric acid. This medicine comes as 100mg and 300mg tablets and is only available on prescription

What is allopurinol dosage during gout attack?

During a gout attack, the usual advice is not to start allopurinol until the flare has settled. However, if you’re already taking it, you should continue the same dose—often 100–300 mg daily—unless your GP advises otherwise. Stopping suddenly can worsen symptoms. Pain and swelling are treated with colchicine or anti-inflammatories, while allopurinol keeps uric acid stable long-term to prevent future attacks.

What is allopurinol hypersensitivity syndrome?

Allopurinol hypersensitivity syndrome is a rare but serious reaction that can occur in some people taking allopurinol. It may cause fever, rash, swelling, liver problems, or kidney issues. In severe cases, it can affect multiple organs. It’s more likely in those with kidney disease or higher starting doses. If you notice a widespread rash, mouth ulcers, or flu-like symptoms, stop taking the medicine and contact your GP immediately.

Can colchicine and allopurinol be taken together?

Yes, colchicine and allopurinol can be taken together safely under medical supervision. They serve different purposes—colchicine helps reduce pain and inflammation during gout flares, while allopurinol lowers uric acid to prevent future attacks. Doctors in the UK often prescribe them together when starting treatment to limit flare-ups. Always follow your GP’s dosing instructions and report any stomach upset, rash, or muscle pain promptly.

What are the questions to ask your doctor before taking Allopurinol tablet?

Is it possible for me to take Allopurinol with other drugs? Should certain beverages, foods and other products be avoided when I take Allopurinol? What are the possible drug interactions of Allopurinol? How will Allopurinol work in my body? How should Allopurinol be taken? How to reduce the risk of Allopurinol drug interactions and side effects?

Warnings and Precautions

The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Allopurinol is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.

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