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Agomelatine

Agomelatine

Agomelatine is prescribed for the treatment of major episodes of depression in adults. This medicine is also used to help prevent the relapse of depression. The common symptoms of depression can include sadness, loss of interest in social activities, anxiety, sleep problems and changes in appetite and weight. Agomelatine helps regulate the disturbances in sleep and appetite patterns caused by depression. This medicine may also be used to treat other conditions as determined by your doctor.
Medically Reviewed by – Dr. Riley Donovan, MD
Last Updated on 8 July 2026

What is Agomelatine used for?

Agomelatine is prescribed for the treatment of major episodes of depression in adults. This medicine is also used to help prevent the relapse of depression. The common symptoms of depression can include sadness, loss of interest in social activities, anxiety, sleep problems and changes in appetite and weight. Agomelatine helps regulate the disturbances in sleep and appetite patterns caused by depression. This medicine may also be used to treat other conditions as determined by your doctor. Agomelatine works by acting on melatonin and serotonin receptors in the brain. Also, by increasing certain natural chemicals, dopamine and noradrenaline, in the brain, Agomelatine helps improve mood and other symptoms of depression. Agomelatine belongs to a class of medicines called antidepressants.

What is the recommended dosage of Agomelatine?

The dosage of Agomelatine prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label. Agomelatine can be taken either with or without food.

What if you miss a dose of Agomelatine?

If your physician has instructed or directed you to take Agomelatine medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses to catch up for the missed dose.

What if you overdose on Agomelatine?

Any medication taken in excess can have serious consequences. If you suspect an overdose of Agomelatine, seek medical attention immediately. Overdose symptoms of Agomelatine may include dizziness, drowsiness, fatigue and anxiety.

What other drugs could interact with Agomelatine?

It may be noted that drugs other than those listed above may also interact with Agomelatine. Agomelatine can interact with the following types of medicines: estrogens, certain antibiotics and antidepressants. Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications (over-the-counter products) and dietary supplements like vitamins, minerals and herbal, which may increase the effect of Agomelatine, so that the doctor can warn you of any possible drug interactions. Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

What are the Agomelatine side effects?

Like many medicines, Agomelatine may cause side effects. If they occur, these are usually mild and short-lived. However, some may be more serious and require medical attention, so it’s important to contact your doctor or go to the nearest hospital straight away. Keep in mind that side effects can vary from person to person and aren’t always predictable. If any new symptoms appear or existing ones worsen, speak with your doctor promptly. Common side effects of Agomelatine include dizziness, headache, stomach pain, constipation, diarrhoea, trouble sleeping, back pain, tiredness, and increased sweating. This isn’t a full list—always follow your doctor’s advice when taking Agomelatine.

Can I Buy Agomelatine Over the Counter in the Australia?

In Australia, Agomelatine isn’t available over the counter. It’s a prescription-only medicine used to treat depression and sleep issues, and you’ll need approval from a qualified doctor before purchase. However, at internationaldrugmart.com, we make things simple. You can consult licensed healthcare professionals online, who can assess your condition and issue a prescription if suitable. Once approved, you can easily order Agomelatine from the comfort of your home and have it delivered discreetly across Australia.

Can I Buy Agomelatine Without a Prescription in Australia?

In Australia, you can’t buy Agomelatine without a prescription. It’s a regulated antidepressant that requires a doctor’s assessment to ensure it’s safe and suitable for you. At internationaldrugmart.com, we make this process easier. You can have an online consultation with a licensed healthcare professional, who can provide a valid prescription if appropriate. Once approved, you can conveniently order Agomelatine online and have it delivered securely to your home anywhere in Australia.

How long does agomelatine take to work?

Agomelatine doesn’t work instantly - it usually takes a few weeks before you start noticing improvements in mood and sleep. Most people begin to feel better within two to four weeks, but for some, it may take a bit longer. It’s important to continue taking it as prescribed, even if you don’t feel an immediate change. Always follow your doctor’s advice and discuss any concerns during treatment to ensure the best results and proper monitoring of your progress.

What is the agomelatine cost Australia?

In Australia, the cost of Agomelatine can vary depending on the pharmacy, location, and whether you’re buying online or in-store. Prices may differ slightly between suppliers. Many Australians choose reputable online pharmacies for affordable options and convenient home delivery. Always ensure you’re purchasing from a trusted source to guarantee safety and quality.

What are the questions to ask your doctor before taking Agomelatine?

Is it possible for me to take Agomelatine with other drugs? Should certain beverages, foods and other products be avoided when I take Agomelatine? What are the possible drug interactions of Agomelatine? How will Agomelatine work in my body? How should Agomelatine be taken? How to reduce the risk of Agomelatine drug interactions and side effects?

Note

The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Agomelatine is safe, appropriate or effective for you. Always consult your health care professional before using this or any other drug. Avoid drinking alcohol while taking Agomelatine. This medicine is not recommended for children and adolescents under 18 years of age.

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