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Acamprosate 333mg
Medically Reviewed by – Dr. Aaron Fletcher, MD
Last Updated on 6 July 2026

Acamprosate 333mg

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Acamprosate 333mg is a prescription medicine used to help adults maintain abstinence after stopping alcohol. It may support brain chemical balance during recovery and is used along with counseling, medical follow-up, and psychosocial support. It is not used for alcohol withdrawal symptoms and should be taken only as prescribed.

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Quick Overview

Acamprosate 333mg is used to support alcohol abstinence in adults who have already stopped drinking and are receiving recovery support.

Product Detail Information
Product Name Acamprosate 333mg
Generic Name Acamprosate Calcium
Strength 333mg
Form Tablet
Drug Class Alcohol abstinence support medication
Main Use Maintenance of abstinence from alcohol
Prescription Status Prescription required
Usual Adult Dose Two 333mg tablets three times daily, as prescribed
Treatment Support Counseling and psychosocial support recommended

What Is Acamprosate 333mg Used For?

Acamprosate 333mg is used to help maintain abstinence in adults with alcohol dependence who have already stopped drinking.

This medicine may help reduce the discomfort linked with alcohol abstinence by supporting brain chemical balance. It works best when combined with counseling, recovery planning, and regular medical follow-up. It is not meant for people who are still drinking heavily or have not completed withdrawal.

How Acamprosate Works

Acamprosate may help restore balance between brain chemical systems affected by long-term alcohol use.

Long-term alcohol use can disturb glutamate and GABA signaling in the brain. Acamprosate is thought to help normalize this balance during abstinence. It does not make a person sick after drinking alcohol, and it does not work like naltrexone or disulfiram.

How To Take Acamprosate 333mg

Acamprosate 333mg is usually taken as two tablets three times daily unless your doctor gives different instructions.

Take the tablets at the same times each day. Many patients take doses with meals to help remember them. Swallow the tablet whole unless your pharmacist confirms otherwise. Do not change your dose, stop early, or restart after a gap without medical advice.

Who Should Use Acamprosate Carefully?

Acamprosate 333mg needs careful medical review in people with kidney disease, depression, suicidal thoughts, pregnancy, or breastfeeding.

Your doctor may check kidney function before prescribing it. Acamprosate is not recommended for severe kidney impairment and may need a lower dose in moderate kidney impairment. Tell your prescriber about your full medical history before starting treatment.

Side Effects

Acamprosate 333mg may cause diarrhea, gas, nausea, appetite changes, dizziness, dry mouth, itching, sweating, anxiety, or sleep problems.

Call your doctor if side effects are severe, persistent, or worrying. Seek urgent help for rash, swelling, severe mood changes, confusion, worsening depression, or thoughts of self-harm. Alcohol recovery itself can affect mood, so monitoring is important.

Drug Interactions

Acamprosate has fewer major interaction concerns than some alcohol-use-disorder medicines, but your doctor still needs your full medication list.

Tell your provider if you take antidepressants, anxiety medicines, sleep medicines, naltrexone, disulfiram, diazepam, prescription drugs, OTC medicines, vitamins, or supplements. Do not start or stop any medicine during recovery without medical guidance.

Buying Acamprosate 333mg Online

Acamprosate 333mg should be purchased with a valid prescription and used under supervision for safe, consistent recovery support.

Before ordering, confirm the prescribed strength, quantity, and dosing schedule. Choose the pack size that matches your prescription and refill plan. Do not share this medicine with another person, even if they have similar alcohol-related concerns.

Storage

Acamprosate 333mg tablets should be stored at room temperature, away from moisture, heat, children, and pets.

Keep tablets in the original packaging until use. Do not use expired medicine, damaged tablets, or tablets that look different from what your pharmacist supplied. Ask your pharmacist how to dispose of unused medicine safely.

FAQ's

What does acamprosate do?

Acamprosate helps adults with alcohol dependence maintain abstinence after they have stopped drinking. It may support brain chemical balance during recovery and reduce abstinence-related discomfort. It is not a cure for alcohol use disorder and works best with counseling, recovery support, and regular medical follow-up.

Can you take acamprosate while drinking?

If you drink while taking acamprosate, continue the medicine and contact your doctor for guidance. Acamprosate does not cause a disulfiram-like reaction with alcohol, but it is intended for people trying to stay abstinent. Drinking may reduce the benefit of treatment and increase relapse risk.

Is Acamprosate 333mg a prescription medication?

Yes. Acamprosate 333mg is a prescription medication. It should be taken only when prescribed by a licensed healthcare provider. Do not start, stop, or change the dose without medical advice.

How long does acamprosate stay in your system?

Acamprosate has a terminal half-life of about 20 to 33 hours after oral dosing. It is mainly cleared by the kidneys, so it may stay longer in people with reduced kidney function. Your doctor may adjust treatment based on kidney health and overall recovery needs.

Is Acamprosate 333mg used for alcohol withdrawal?

Acamprosate 333mg is not used to treat alcohol withdrawal symptoms. It is usually started after withdrawal, once the person has stopped drinking. Alcohol withdrawal can be serious and may require medical supervision, especially if there are tremors, seizures, confusion, vomiting, or severe anxiety.

How long does Acamprosate 333mg take to work?

Acamprosate 333mg does not work as an instant craving blocker. Some people notice support after consistent use, while others need more time and structured recovery care. Taking each dose as prescribed, attending counseling, and avoiding alcohol are important for better treatment outcomes.

Is Acamprosate 333mg available over the counter in the US?

Acamprosate 333mg is not available over the counter in the US. It is a prescription medication used for alcohol abstinence support. A healthcare provider should evaluate your alcohol history, kidney function, mental health, and current medicines before deciding whether acamprosate is suitable.

Medical Disclaimer

This page is for educational purposes only and does not replace advice from a licensed healthcare professional. Always follow your doctor’s prescription, diagnosis, and treatment plan. Read the medical disclaimer before using this information for health decisions.

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