Escitalopram vs Sertraline
Drug Class
Selective Serotonin Reuptake Inhibitor (SSRI)
Selective Serotonin Reuptake Inhibitor (SSRI)
Common Brand Name
Lexapro
Zoloft
Primary Use
Major depressive disorder, generalized anxiety disorder
Major depressive disorder, social anxiety disorder, panic disorder, PTSD, OCD
Mechanism of Action
Increases serotonin levels by inhibiting reuptake
Increases serotonin levels by inhibiting reuptake
Typical Starting Dose (Adults)
10 mg once daily
25–50 mg once daily
Maximum Dose (Adults)
20 mg/day
200 mg/day
Half-Life
~27–32 hours
~26 hours
Onset of Action
1–2 weeks for initial effect, up to 6–8 weeks for full response
1–2 weeks for initial effect, up to 6–8 weeks for full response
Common Side Effects
Nausea, insomnia, headache, dry mouth, sexual dysfunction
Nausea, diarrhea, insomnia, dizziness, sexual dysfunction
Withdrawal Symptoms
Possible if stopped suddenly: dizziness, irritability, flu-like symptoms
Possible if stopped suddenly: dizziness, irritability, nausea
Drug Interactions
MAOIs, NSAIDs, anticoagulants, other serotonergic drugs
MAOIs, NSAIDs, anticoagulants, other serotonergic drugs
Pregnancy Category
Category C (consult your doctor)
Category C (consult your doctor)
Cost (Generic)
Generally low-cost generic available
Generally low-cost generic available
Key Differences
Often preferred for anxiety; simpler dosing
Broader approval for anxiety, OCD, PTSD; titratable doses
Coupon
Frequently Asked Questions
Which is better for anxiety: Escitalopram or Sertraline?
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Both are effective, but Escitalopram is often preferred for generalized anxiety disorder (GAD). Sertraline is frequently used for social anxiety disorder (SAD) and post-traumatic stress disorder (PTSD).
Do they have different side effects?
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Their side effects are similar: nausea, insomnia, and sexual dysfunction. Sertraline may cause more diarrhea, while Escitalopram sometimes causes more dry mouth.
Which works faster?
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Both drugs start working in 1 2 weeks, but full benefits may take up to 6 8 weeks.
Can I switch between them?
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Yes, under doctor supervision. Switching may help if one causes intolerable side effects.
