Paroxetine vs Sertraline

Paroxetine

Sertraline

Brand Names

Paxil, Pexeva

Zoloft

Drug Class

Selective Serotonin Reuptake Inhibitor (SSRI)

FDA Approved Uses

Major depressive disorder, Obsessive-compulsive disorder, Panic disorder, Social anxiety disorder, etc.

Major depressive disorder, Obsessive-compulsive disorder, Panic disorder, Post-traumatic stress disorder, etc.

Common Side Effects

Nausea, Drowsiness, Dizziness, Insomnia, Loss of appetite, Increased sweating, Dry mouth, Sexual dysfunction

Nausea, Drowsiness, Dizziness, Insomnia, Diarrhea, Fatigue, Dry mouth, Sexual dysfunction

Dosage Form

Oral tablet, Oral suspension, Extended-release oral tablet

Oral tablet, Oral concentrate

Dosage

Initial dose typically 20 mg once daily, can be adjusted up to 50 mg depending on condition

Initial dose typically 50 mg once daily, can be adjusted up to 200 mg depending on condition

Half-Life

21 Hours

26 hours

Interactions

Strong CYP2D6 inhibitors, other SSRIs, MAO inhibitors, anticoagulants, NSAIDs, aspirin, etc.

CYP2D6 inhibitors, other SSRIs, MAO inhibitors, anticoagulants, NSAIDs, aspirin, etc.

Contraindications

Use of MAO inhibitors or thioridazine within 14 days, severe renal and liver impairment

Use of MAO inhibitors within 14 days, pimozide, severe renal and liver impairment

Pregnancy Category

D (Evidence of risk)

C (Risk not ruled out)

Alcohol Interaction

Alcohol can increase the nervous system side effects of paroxetine such as dizziness, drowsiness, and difficulty concentrating.

Alcohol can increase the nervous system side effects of sertraline such as dizziness, drowsiness, and difficulty concentrating.

Mechanism of Action

Inhibits the reuptake of serotonin in the brain, enhancing mood-regulating effects

Withdrawal Symptoms

Dizziness, Sensory disturbances, Sleep disturbances, Anxiety, Headache

Dizziness, Irritability, Agitation, Anxiety, Headache

Coupon

Coupon Code

IDMBLG30

Use This Coupon To Buy

Coupon Code

IDMBLG30

Use This Coupon To Buy

Frequently Asked Questions

What's the difference between Paroxetine and Sertraline?

Paroxetine and Sertraline are both used to treat depression and anxiety. But they are different medicines. Paroxetine may cause more sleepiness and weight gain. Sertraline is often easier to take with fewer side effects for many people.

Which one works faster, Paroxetine or Sertraline?

Both can take a few weeks to start working. Some people may feel better faster on Sertraline, but it depends on your body. Your doctor will help you choose the one that's right for you.

Is Paroxetine stronger than Sertraline?

Not really. One isn't stronger than the other. They just work in different ways for different people. What works best depends on your symptoms and how your body reacts.

Can I switch from Paroxetine to Sertraline?

Yes, but only with your doctor's help. Switching must be done slowly to avoid side effects. Never stop or change your medicine without talking to your doctor first.

Tirzepatide vs Semaglutide

→

Trazodone VS Xanax

→