Cabergoline vs Bromocriptine
Drug Class
Dopamine agonist
Dopamine agonist
Brand Names
Dostinex, Cabaser
Parlodel, Cycloset
Primary Use
Hyperprolactinemia (high prolactin levels), Parkinson’s disease
Hyperprolactinemia, Parkinson’s disease, type 2 diabetes (Cycloset)
Mechanism of Action
Stimulates dopamine receptors, suppresses prolactin secretion
Stimulates dopamine receptors, suppresses prolactin secretion
Dosing Frequency
Typically twice weekly
Daily to several times daily
Half-Life
~63–69 hours
~6–15 hours
Onset of Action
Within 3 hours
Within 1–2 hours
Duration of Action
Long-acting
Shorter-acting
Common Dosages
0.25 mg to 1 mg twice weekly (may be adjusted)
2.5 mg 1–3 times daily (depends on condition)
Effectiveness in Lowering Prolactin
More potent and better tolerated
Effective, but may require higher doses
Use in Pregnancy
Category B – may be used with caution
Category B – more commonly studied in pregnancy
Side Effects
Nausea, dizziness, constipation, fatigue, low BP, nasal stuffiness
Nausea, vomiting, headache, dizziness, hypotension, confusion
Drug Interactions
Caution with antihypertensives, macrolides, psych meds
Same as Cabergoline
Coupon
Frequently Asked Questions
Which is more effective for high prolactin, Cabergoline or Bromocriptine?
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Cabergoline is generally more effective and better tolerated for lowering prolactin levels than Bromocriptine.
Can I take Cabergoline or Bromocriptine during pregnancy?
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Bromocriptine is more commonly used in pregnancy, but Cabergoline may be used under medical supervision.
Which has fewer side effects?
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Cabergoline usually causes fewer side effects due to less frequent dosing.
Do I need to take these drugs daily?
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Bromocriptine is taken daily, while Cabergoline is usually taken twice weekly.
